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Beilstein J. Org. Chem. 2017, 13, 2153–2156, doi:10.3762/bjoc.13.214
Graphical Abstract
Figure 1: Biologically active naturally occurring cyclic tetrapeptide HDAC inhibitors.
Scheme 1: Reagents and conditions: (i) Triethyl phosphonoacetate, n-Bu4N+I−, aq K2CO3, rt, 18 h, 86%; (ii) H2...
Scheme 2: Reagents and conditions: (i) Grubbs’ catalyst 12 (2.5 mol %), DCM, reflux, 2 h, 14a, 83%; 14b, 90%; ...